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KMID : 1035620170050040223
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Allergy Asthma & Respiratory Disease
2017 Volume.5 No. 4 p.223 ~ p.227
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Serum micronutrients levels and clinical features of elderly asthmatics
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Lee So-Hee
Song Woo-Jung
Park Heung-Woo
Kim Se-Hoon
Park Hye-Kyung
Kim Sang-Heon
Kwon Yong-Eun
Kim Tae-Bum
Lee Byung-Jae
Jee Young-Koo
Choi Byoung-Whui
Cho Sang-Heon
Kim Sun-Sin
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Abstract
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Purpose: The prevalence of asthma in the elderly is rapidly increasing. However, we do not fully understand the pathogenesis of elderly asthma, especially for the roles of micronutrients. This study aimed to evaluate the associations between serum levels of micronutrients, including several vitamins and minerals, and clinical features of the elderly asthmatics.
Methods: A total of 317 asthmatics aged 65 or older were enrolled. Serum levels of vitamin D, vitamin B12, folate, Mg, and Se were measured and then the associations between serum micronutrient levels and clinical features of elderly asthmatics were evaluated.
Results: Positive correlations with significance among serum levels of vitamin B12, vitamin D, and folate were found. Serum micronutrients levels showed no difference according to the atopic status and symptom severity. The serum folate level was significantly associated with forced expiratory volume in 1 second, and serum vitamin B12 and folate levels were significantly associated with serum total IgE level. Interestingly, elderly asthmatics with exacerbation history showed significantly lower serum levels of vitamin D and Mg, but significantly higher serum levels of Se.
Conclusion: Serum levels of micronutrients, such as vitamin D, vitamin B12, Mg, folate, and Se, were significantly associated with some clinical features of elderly asthmatics. Clinical meanings of these associations need to be investigated further.
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KEYWORD
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Elderly, Asthma, Micronutrients
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